Metastatic Colorectal Cancer: Sound Strategies for Selecting First-Line Therapies

Release Date: November 25, 2009
Expiration Date: November 24, 2010

Media
Slides with interactive questions. Printable PDF also available.

Target Audience
This activity is intended for hematologists, oncologists, oncology nurses, oncology/specialty pharmacists, and others who are involved with the care of patients with metastatic colorectal cancer (mCRC).

Statement of Need
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the second leading cause of cancer death in the United States. Approximately 149,000 new cases are diagnosed each year. At the time of presentation, about 20% of patients with CRC will have metastatic disease. Cure at this stage is rarely possible, although some patients whose metastases are limited (especially if to the liver or lung) may be "cured" by surgical means. For most sufferers of mCRC, however, treatment is palliative, offering prolonged survival, improvement in symptoms, and enhanced quality of life.

Educational Objectives
On completion of this activity, participants should be able to:
  • Evaluate and assess current findings in the management of mCRC
  • Identify current first-line therapies, both chemotherapeutic and biologic agents, and practices in mCRC
  • Tailor a therapeutic regimen to meet the needs of the individual patient with mCRC
  • Employ select strategies to minimize exposure to ineffective therapies and their toxicities
Faculty Information and Disclosures

Neal P. Christiansen, MD click here for bio
Assistant Professor of Medicine
Medical University of South Carolina
Division of Hematology/Oncology
Charleston, South Carolina



Disclosures:
Dr Christiansen has received consultancy fees from sanofi-aventis and Genentech.

Off-label use of cetuximab (in patients in whom irinotecan has not failed) and bevacizumab (continuing after first-line therapy) will be discussed in this presentation.

Conflict resolution: This presentation has been peer reviewed for evidence base and fair balance.

Instructions
To receive a statement of credit, you must:
  • Review the content of the activity.
  • Successfully complete the post-test (70% or higher).
  • Complete the evaluation at the end of the activity.
Your statement of credit will be issued immediately upon successful completion of the post-test and submission of the evaluation.

Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of California, Irvine School of Medicine (UCI) and Center of Excellence Media, LLC. The University of California, Irvine School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement
The University of California, Irvine School of Medicine designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This activity is complimentary.

General Disclosure Statement
It is the policy of the University of California, Irvine School of Medicine and the University of California CME Consortium to ensure balance, independence, objectivity, and scientific rigor in all CME activities. Full disclosure of conflict resolution will be made in writing via handout materials or syllabus.

Bonnie Carroll, Director, CME, UC Irvine School of Medicine, has no financial or other relationship to products or devices with commercial interests related to the content of this CME/CE activity.

Center of Excellence Media, LLC: The planners and managers have nothing to disclose related to the content of this activity.

Erica Johansson, RN, Astute CE, LLC, has nothing to disclose related to the content of this activity.

Dr. Randall F. Holcombe, University of California, Irvine School of Medicine, peer-reviewed the content for evidence base and fair balance. Dr Holcombe has no real or apparent conflicts of interest related to this activity.

Conflict resolution: This presentation has been peer reviewed for evidence base and fair balance.

This activity is in compliance with California Assembly Bill 1195, which requires continuing medical education components to include curriculum in the subjects of cultural and linguistic competency. For specific information regarding Bill 1195 and definitions of cultural and linguistic competency, please visit the CME Web site at http://www.cme.uci.edu.
   

This activity is supported by an educational grant from Genentech BioOncology.


Software Requirements
PC
Internet Explorer 5.5 or greater
Firefox
Windows 2000 or greater
Sound Card & Speakers
800 x 600 Minimum Monitor Resolution
(1024 x 768 Recommended)
Flash Player Plug-in (9.0 or later)
*Adobe Acrobat Reader

*Required to view Printable PDF Version
Mac OS 10.2.8
Safari
Firefox
Sound Card & Speakers
800 x 600 Minimum Monitor Resolution
(1024 x 768 Recommended)
Flash Player Plug-in (9.0 or later)
*Adobe Acrobat Reader


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